Endocrine Abstracts

Injected depot formulations of somatostatin peptide analogs are routinely used to treat acromegaly and neuroendocrine tumors (NETs). Paltusotine (CRN00808), a small molecule nonpeptide selective somatostatin receptor 2 (sst2) agonist, is being evaluated for efficacy and safety in patients with acromegaly. The current Phase 1 study (NCT04246749) was conducted in two Parts: In Part A, the absorption, metabolism, excretion, and mass balance of a single oral dose of 20 mg [14C]-pa...

Background: The 2019 coronavirus disease (COVID-19) pandemic is a public health emergency and raises the issue of psychological and physical resilience in more vulnerable patients. We investigated the emotional impact of the SARS-CoV-2 spread among cancer patients, followed at our Institution in Italy, after the restrictive measures imposed by the government and the disruption of planned clinical activities.Methods: From March 18th to April 1st, 2020, we...

Introduction: The purpose of this study was to describe the clinical characteristics of patients with macroprolactinoma in a second level Hospital.Methods: Retrospective data collection of patients diagnosed with macroprolactinoma between 2002 and 2017 at Jerez University Hospital.Results: Complete Data were obtained from 22 patients. The mean age at diagnosis was 40.32 ± 18.3 years (men: 52.9 ± 14.2, women: 27.7 ± 1...

Introduction: Papillary carcinoma is the most common form of well-differentiated thyroid cancer (80% of the total). In recent years there has been a significant progressive increase in prevalence.Objectives: The aim of the study was to evaluate the clinical characteristics of the newly diagnosed papillary thyroid carcinoma at the Sanitary Area of Jerez, as well as to analyze its incidence in recent years.Material and Methods: An ob...

Obesity and thyroid function in children – cross-sectional study.Background: Obesity in children has been increasing dramatically, with a significant increase in cardiovascular and metabolic diseases risk. The role of thyroid dysfunction has been extensively analyzed in obese adults, but to a limited extent in children.Aims: To estimate the prevalence of hyperthyrotropinemia in obese children and to analyze the influence of BM...

Context: In the background population, maternal TSH levels >2.5 mUI/l in late pregnancy have been reported to be associated with breech presentation. This has not been addressed in women treated with levothyroxine.Aim: Our aim was to study the relationship of 3rd trimester maternal TSH with caesarean section (CS) due to foetal malposition in pregnant women treated with levothyroxine since before pregnancy.Methods: We have studi...

Introduction: The presence of undetectable serum levels of stimulated thyroglobulin (Tg) with negative imaging tests is the criterion used to define remission in low-risk differentiated thyroid cancer (DTC). Most guidelines recommend 131-I ablation after thyroidectomy to remove any possible residual thyroid tissue. Our aim was to know how often undetectable Tg levels are achieved before ablation to avoid unnecessary radiation treatments.Patients and meth...

The effects in vitro and in vivo of somatostatin (SS) analogues are linked to the presence of specific binding sites on target cells. Estradiol (E2) may modulate the expression of SS receptors (SSTR) in some cell models, including breast cancer and pituitary cells. Aim of this study was to evaluate the effects of E2 on SSTR1-5 ligand binding domains (LBD) expression levels in prostate epithelial cells (PEC).Methods: We investigated the effe...

In vertebrates, ARs have been detected in spermatogonia and also fetal gonocytes, confirming the importance of testosterone for the initial process of spermatogenesis. During seasonal spermatogenesis of adult bullfrogs (Lithobates catesbeianus), primordial germ (PG) cells show testosterone immunoexpression in winter; however, a weak or none testosterone immunoexpression was detected in summer. With the aim to confirm the role of testosterone in these cells, the immunogold loca...

Background: Pseudohypoaldosteronism type 1 (PHA1) is a primary form of mineralocorticoid resistance presenting in the newborn with renal salt wasting, failure to thrive and dehydration. Inactivating mutations of the NR3C2 gene, coding for the mineralocorticoid receptor (MR) are responsible for the vast majority of autosomal dominant and sporadic cases of renal PHA1. The underlying pathogenic mechanism involves both haploinsufficiency as well as a dominant negative mecha...